LAT polyclonal antibody
产品名称： LAT polyclonal antibody
英文名称： LAT polyclonal antibody
产品编号： PAB17296
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152
- 传真 : +886-2-8751-1186
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of LAT.
- Immunogen:
- A synthetic peptide corresponding to residues surrounding serine 363 of human LAT.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse
- Specificity:
- This antibody detects endogenous levels of total LAT protein.
- Form:
- Liquid
- Storage Buffer:
- In PBS, pH 7.4 (150mM NaCl, 0.02% sodium azide, 50% glycerol)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (1:500-1:1000)
ELISA (1:5000)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- The four distal tyrosines are required for LAT-dependent signaling in FcepsilonRI-mediated mast cell activation.
Saitoh S, Odom S, Gomez G, Sommers CL, Young HA, Rivera J, Samelson LE.J Exp Med. 2003 Sep 1;198(5):831-43.
- 2.
- Identification of a membrane protein, LAT-2, that Co-expresses with 4F2 heavy chain, an L-type amino acid transport activity with broad specificity for small and large zwitterionic amino acids.
Pineda M, Fernandez E, Torrents D, Estevez R, Lopez C, Camps M, Lloberas J, Zorzano A, Palacin M.J Biol Chem. 1999 Jul 9;274(28):19738-44.
- 3.
- A LAT-associated function reduces productive-cycle gene expression during acute infection of murine sensory neurons with herpes simplex virus type 1.
Garber DA, Schaffer PA, Knipe DM.J Virol. 1997 Aug;71(8):5885-93.
- Entrez GeneID:
- 27040
- Protein Accession#:
- O43561
- Gene Name:
- LAT
- Gene Alias:
- LAT1,pp36
- Gene Description:
- linker for activation of T cells
- Omim ID:
- 602354
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq
- Other Designations:
- 36 kDa phospho-tyrosine adaptor protein